Abstract

EVALUATION OF HEPATOPROTECTIVE AND ANTI-INFLAMMATORY ACTIVITIES OF NEPHELIUM LAPPACEUM L. IN VITRO

Destin Joseph*, Aswini Edathile Valappil, Vivek Devaraj, Aleena Aliyar and Anaswara Kizhakke Thottumkara

ABSTRACT

Hepatic disorder is fatal affecting all individuals of different age and it is a leading cause of death in this world. There are many herbals, synthetic anti-hepatotoxicant agents used to treat liver diseases. This review is based on in vitro hepatoprotective and anti-inflammatory activity study of the leaf extract of Nephelium lappaceum L. The in vitro hepatoprotective study (MTT assay using HepG2 cell lines) and anti-inflammatory studies like human red blood cell (HRBC) membrane stabilization, protein denaturation, cyclooxygenase-2 (COX-2), and 5- lipoxygenase (5-LOX) assay were carried out. The petroleum ether extract of Nephelium lappaceum shows significant hepatoprotection in HepG2 cell line, increases percentage protection in HRBC membrane stabilisation and percentage inhibition in protein denaturation, COX-2 and 5-LOX assay. The extract of Nephelium lappaceum L. leaves be revealed remarkable hepatoprotective and anti-inflammatory activities.

Keywords: Nephelium lappaceum L, Hepatoprotective, Anti-inflammatory, Carbon tetrachloride.