Abstract

PROTECTIVE ROLE OF POLYBION AGAINST RADIATION AND CADMIUM INDUCED HAEMATOLOGICAL CHANGES IN SWISS ALBINO MICE

Damodar Kumar Joiya*

ABSTRACT

In the present atomic age uses of radiation and radioisotopes has increased many fold in the fields of radio diagnosis, radiotherapy, industries, agriculture, nuclear research etc. Diagnostic and therapeutic use of radiation is of prime importance and their effects especially haematopoietic and other systems has attracted the intersest to minimize them by using some agents. In the recent years, immense intrest has been developed[2] in the field of chemoprotection against radiation and heavy metals induced changes. Therfore,[1] Our study aims to investigate the protective effect of polybion against combined exposure of radiation and cadmium chloride on blood of Swiss albino mice. Considering this state of affairs, the present study was to evaluate the protective effect of Polybion against cadmium and radiation induced haematological alteration in Swiss albino mice. The animal were exposed to 5.0Gy of gamma rays with or without cadmium chloride treatment. The Polybion was administered since seven days prior to irradiation or cadmium chloride treatment and upto the last autopsy interval. The animals from all the experimental groups were sacrificed by cervical dislocation at each post-treatment interval of 1,2,4,7,14 and 28 days. The weight of animal[3] was recorded before the autopsy. Five normal mice were also autopsied. Immediately after the autopsy the blood was collected by cardiac puncture in heparinized tubes for various haematological studies. The various haematological parameters were estimate ie.R.B.C., W.B.C., Hb., PCV, MCV, MCH, MCHC, DLC, SGOT, SGPT. After[1] combined treatment of radiation and cadmium additive effects were noted. The Polybion pretreated mice showed less severe changes in comparision to the non drug treated animals at all the corresponding intervals. An early and fast recovery was also observed in Poybion treated groups. Thus it appears the Polybion is potent enough to check radiation and cadmium induced haematological changes in Swiss albino mice. I.[8]

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