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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript

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WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

STABILITY INDICATING ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF NALTREXONE AND BUPROPION HCL IN BULK AND TABLET DOSAGE FORM BY UPL

Hafsa Habeeb* and S. H. Rizwan

ABSTRACT

This research paper has a Simple sensitive, cost effective, precise Ultra Performance liquid chromatography method for The Simultaneous Estimation of Naltrexone and Bupropion HCL in bulk and Tablet Dosage Form was developed and validated in accordance to ICH guidelines. The chromatography was carried out on water x bridge (75*4.6mm & 2.7μm) column using a mixture of ammonium acetate buffer pH 4.0: methanol (65:35) as the mobile phase and it was pumped at a flow rate of 0.6ml/min the detection was carried out at 275 nm the retention time of naltrexone and bupropion was observed at 2.316 min and 3.907 min respectively with good peak shape, resolution (>1.5) and tailing factor (

Keywords: Naltrexone, Bupropion, Mobile phase, run time.

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