Abstract

FLOATING DRUG DELIVERY SYSTEM: AN EMERGING NOVEL DRUG DELIVERY TO IMPROVE GASTRORETENTION OF DRUG

Bhavin D. Pandya*, Janvi K. Modi, Meenakshi Patel and Ashok N. Mahajan

ABSTRACT

Gastroretentive drug delivery system is a novel drug delivery system which has an upper hand owing to its ability of prolonged retaining ability in the stomach and thereby increase gastric residence time of drugs and also improves bioavailability of drugs. The purpose of this review is Floating drug delivery system is to compile the recent literature with special focus on the principal mechanism of floating to achieve gastric retention. The floating drug delivery system floats on a gastric fluid in the stomach and the drug is released slowly at the desired rate from the system. The recent developments of floating drug delivery system including the factors affecting gastric retention, approaches to design single-unit and multiple-unit floating systems, and their classification. This review also summarizes the in vitro techniques as well as in vivo studies to evaluate the performance of the floating drug delivery system. The approaches, mechanisms, advantages, disadvantages, different types of floating drug delivery system and the marketed formulations of the floating drug delivery system has been mentioned in this review and also it has mentioned the work done in past on the floating drug delivery system.

Keywords: Floating drug delivery system (FDDS), gastro retentive drug delivery system (GRDDS), novel drug delivery system (NDDS), gastric retention, bioavailability.