Abstract

EFFECT OF SYNERGY OF COLISTIN / VANCOMYCIN AGAINST STRAINS OF ACINETOBACTER BAUMANNII BY E-TEST METHOD IN RABAT

*Es-Said Imane, Ousti Fadwa, Zouhdi Mimoun

ABSTRACT

Multidrug-resistant Acinetobacter baumannii (MDRAB) presents a major health problem. Although colistin has-been used as a treatment of last resort, but it was still considered as a nephrotoxic antibiotic. The mechanism of Action of colistin, however, raises the possibility of synergy with other molecules that are normally inactive against Gramnegative organisms by virtue of the impermeability of the bacterial outer membrane. This study evaluated the effect of colistin combined with vancomycin on fifty strains of A. baumannii multiresistant, except for colistin, by using Etest methods. For all the isolates, significant synergy was demonstrated with reductions in the MIC of vancomycin from> 256 mcg / ml to ≤ 12 mg / ml for all strains after exposure to 0.5 mg / ml colistin. This raises the possibility of the clinical use of this combination for infections due to MDRAB, with the potential for doses lower than those currently used.

Keywords: Colistin, vancomycin, synergy, Acinetobacter baumannii