Abstract

?- GLUCO-OLIGOSACCHARIDE ASSOCIATED TO EUDRAGIT® FS 30 D IN ISOLATED FILMS: A CANDIDATE FOR THE MODIFIED RELEASE SYSTEM

Daniele Schaab Boff Junges, Camila Borges Villas-Boas, Isabela Angeli de Lima, Osvaldo Albuquerque Cavalcanti and Élcio José Bunhak*

ABSTRACT

Colon-specific drug release has been increasingly studied, aiming at the treatment of diseases that affect this region. Isolated films were prepared by the casting method, incorporating the α-gluco-oligosaccharide (Bioecolians® or α-GOS) prebiotic to the Eudragit® FS30D (FS) polymer, in different proportions such as FS:α-GOS: 100:00, 95:05, 90:10, and 80:20. The properties of the films were evaluated based on the study of water vapor transmission (WVT), determination of the swelling index (Si%), Fourier transform infrared spectroscopy (FTIR), micro Raman spectroscopy, and scanning electron microscopy (SEM). The combination of α-GOS and FS gave rise to a material with good filmogenic capacity; in addition to this, the incorporation of the oligosaccharide to the polymer did not alter the chemical structure of the constituents. The films developed showed to be a promising material for coating solid pharmaceutical forms of colon- specific release, mainly due to their synergistic capacity of pH and enzyme dependence. Thus, it is believed that the films will be able to protect the drug during gastrointestinal transit, allowing the attack by the bacteria in the colon region to α-GOS, thus promoting the release of the drug.

Keywords: Biotechnology; Pharmaceutical Industry; Research Design.