Abstract

A COMPREHENSIVE REVIEW ON COLON TARGETED DRUG DELIVERY SYSTEM

Ajit Kumar Varma, Neha Dubey, Gaurav Dubey, Jamshed Ali, Anurag Chourasia, Akash Limba Kawale and Sahildeep Singh*

ABSTRACT

Although significant interest in colon-specific drug delivery systems has been placing over the past few years to create a delivery system capable of releasing medications in the colon in a reliable and replicable manner, these attempts have been unfruitful so far. The colon is an area that can host both local and systemic medication delivery. Drug administration should begin in the proximal colon and be supported by protecting drugs against breakdown, absorption, and release. The purpose of this evaluation is to grasp recent advances in treatment approaches for dosage types that are currently designed to administer colon therapies utilizing a pH-sensitive framework, a microbially initiated system like prodrugs, and polysaccharide-based techniques.

Keywords: Colon-specific drug delivery, pH-sensitive, time-controlled dependent, microbially triggered, pressure controlled, and osmotically controlled system.