Abstract

BIOADHESIVE SUBLINGUAL TABLET: A NEW TECHNOLOGY ORIENTED FORMULATION WITH MULTIPLE BENEFITS

Jyothi Lakshmi V. Nair* and Sneha Thankachan

ABSTRACT

Oral delivery is currently the gold standard in the pharmaceutical industry where it is regarded as the safest, most convenient and most economical method of drug delivery having the highest patient compliance. Formulation of a convenient dosage form for oral administration, by considering swallowing difficulty especially in case of geriatric and pediatric patient leads to poor patient compliance. Drug delivery through the oral mucous film is considered to be a promising contrasting option to the oral course. Mucoadhesive buccal film is developed as a promising dosage form, which has prominent advantages because of drug delivery through buccal mucosa. The buccal mucosa is rich in blood supply and relatively permeable. Buccal cavity was found to be most accessible site for both local and systemic delivery of drug. Sublingual course is a quick onset of activity and preferred patient consistence over orally ingested tablets. Sublingual (contracted SL), from the Latin for "under the tongue", alludes to the pharmacological course of organization by which drugs diffuse into the blood through tissues under the tongue. Sublingual course is a valuable when fast onset of activity is wanted with preferable patient consistence over orally ingested tablets. Regarding penetrability, the sublingual al range of the oral pit (i.e. the floor of the mouth) is more porous than the buccal (cheek) range, which thusly is more penetrable than the palatal (top of the mouth) territory. This review highlights that the oral mucosal drug delivery by discussing briefly the structural feature of mucosa, mechanism and theories of bio adhesion. It also contains mucoadhesive polymer, evaluation methods and some of the review on reported research work done on different types of drug by using different mucoadhesive polymers.

Keywords: Bio adhesive, Sublingual tablet, Bioavailability.