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FORMULATION AND EVALUATION OF THE DRAGÉE OF ONDANSETRON HYDROCHLORIDE
Obed Singh* and Dr. Ashutosh Badola
ABSTRACT The objective of present study was to develop Dragée of model drug Ondansetron. This type of dosage form contains active ingredient which has an unpleasant taste or odor that may be covered with sugar to make it more palatable. The shape, size and color are all visual characteristics reflected by the core the form of the core may be a key thing about the general appearance of the Pharmaceutical table Dragée are mainly focus of recent research due to its advantages like promoting higher compliance, advantage for patients who have difficulty in swallowing tablets. Its active compounds absorbed at oral level avoid the hepatic circulation. The main focus of recent research due to its advantages like it enhances the bioavailability of oral drugs, reduced dosing frequency and the tendency of acceptability from people of all ages. In pharmaceutical products, there are various sorts of Tablets during a range of physical appearances, from high-gloss, rounded, sugar coated pieces to the geometric, punched shapes of film coated products. The shape, size and color are all visual characteristics reflected by the core and therefore the coating like sugar coat, film coat. the form of the core may be a key think about the general appearance of the Pharmaceutical tablet, indirectly as a cosmetic influence, rather because the foundation for an applied coating system. The aim of the current project is to formulate and evaluate the Dragée of Ondansetron Hydrochloride, and to debate the benefits and limitation of Dragée a drug delivery system, its methods of preparation, advantage, manufacture, process of preparation, Dragée coating, Dragée machinery features, stability, factor effecting release with reference to the medicated chewing gums. The first step in the current research was the preformulation studies of the drug. The given drug was subjected for different preformulation tests like organoleptic properties, melting point, determination of pH, partition coefficient, solubility in different solvents, absorbance maxima (max) by UV, preparation of standard curve and FT-IR. Hence it was concluded that Dragée of ondansetron may improve bioavailability followed by patient compliance. Keywords: Novel Drug Delivery System, Dragée, Average Cumulative Percentage Drug Releas, Fourier-transform infrared spectroscopy. [Download Article] [Download Certifiate] |