Abstract

SYNTHESIS, CHARECTIRIZATION & PHARMACOLOGICAL ACTIVITY OF 1, 2, 4 TRIAZOLE DERIVATIVES (Z)-1(benzo[d]thiazole-2-yl (1 subsituted phenylidene) hydrazine CONTAINING BENZOTHIAZOLE

Sangeeta Kmari*, Sujeet Kumar Gupta and Sandeep Kumar

ABSTRACT

The present study we have entire an effort to synthesize new triazole products (4a-f) and (5a-f) measure them for anti-convulsion action through Maximal electrode shock attack method. First step, we synthesized reacted with aniline and potassium thiocynate through using bromine solution and glacial acetic acid formaylation gave complex 6- chlorobenzo[d] thiazole-2-amine (2). 6- chlorobenzo[d] thiazole-2-amine was once responded by way of 6- chlorobenzo[d] thiazole-2-amine in the occurrence of Ethylene Glycol, answer and hydrazine hydrate to presents 1-(6-chlorobenzo[d] thiazole-2yl) hydrazine(3a). Complex (3a) used to be allowable to reply with numerous substituted potassium thiocynate offers conforming triazole products. Triazole products (3a) had been replied through acetophenone and giacial acetic acid and ethanol at reflux for 5h to offers afforded complexes (4a-f) and (5a-f). last triazole (Z)-1-(benzo[d] thiazole-2-yl)-2-(1-subsituted phenyl-thylidene) hydrazine (5a-f), were synthesized from substituted acetophenone through the response with ethanol. Final complicated has been set up on the basis of 1H NMR. and FTIR. The values of 1H NMR, FTIR, TLC and, Solubility have been established to be projecting. Pharmacological screening thru ear electrode prompted cutting-edge 51mA for 0.3 2d in electro-convulsiometer for anti-conversant activity. The synthesized compound used to be mounted to be 5a. 5b, 5c, 5d ,5e and 5f. The complicated 5c and 5d was once set up to be maximum powerful complicated with associate to general medications phenytoin sodium.

Keywords: MES (Maximal electroshock seizure) method, Anti-convulsant Activity, phenytoin sodium, triazole electro convulsiometer.