Abstract

SYNTHESIS, CHARACTERIZATION & BIOLOGICAL ACTIVITY OF SOME N9-(ARYLIDENE ACETYLHYDRAZINO)-CARBAZOLE NOVEL CARBAZOLE DERIVATIVE

Sandeep Kumar* and Sujeet Kumar Gupta

ABSTRACT

In current study, we attempted to synthesize six new derivatives of carbazole (4a-4e) and test them for their anti- -inflammatory activity using the carrageenan induced inflammation model in rat paw edema model. In scheme We synthesized N9-(chloroacetyl)-carbazole then react with hydrazine hydrate to give N9-(hydrazinoacetyl)-carbazole was further reacted with various substituted aldehyde in the presence of ethanol and dioxan and found to six derivative of carbazole (4a-4e). The structure of final product has been confirm by FTIR and 1H NMR. Value of FTIR, 1H NMR and Thin layer chromatography was found to be significant. All biological activity screening by carrageenan induced inflammation in rat hind paw edema model. The compound 4d & 4e most potent compound with compared to Diclofenc.

Keywords: Rat paw, inflammation, carrageenan, carbazole.