Abstract

SYNTHESIS, CHARACTERIZATION & SCREENING FOR ANTI-INFLAMMATORY ACTIVITY OF SOME 4-(4,5-DIPHENYL-1H-IMIDAZOL-2-YL)-3,1-SUBSTITUTED PHENYL-1H PYRAZOLE DERIVATIVES

Lavkush Tiwari*, Shobhit Srivastava and Sujeet Kumar Gupta

ABSTRACT

A novel series of substitute imidazole derivatives were synthesized and their anti-inflammatory activity was evaluated. In the first step, we synthesize substituted acetophenone phenylhydrazone (3) by using substituted acetophenone (1) and substituted phenyl hydrazine (2) in presence of acetic acid and water, which is then converted in to Substituted- 1H-pyrazole-1-carbaldehyde (4) via vilsmeier-Hack method. Further, Substituted-1H-pyrazole-1-carbaldehyde (4) was reacted with benzil and ammonium acetate in glacial acetic acid to give corresponding 4-(4,5-diphenyl-1H-imidazol-2-yl)-3,1-substituted phenyl -1H-pyrazole (6a-g). FTIR and 1H NMR confirmed the structures of the synthesized compounds. The anti-inflammatory effect of the compounds was evaluated with Rat PAW edema In rats. In pharmacological screening, compound was found most potent compound with compare to standard drug Diclofenac sodium. The promising results encourage future research into the rational modification of this nucleus for better compound development.

Keywords: Imidazole, Radziszewski reaction, Anti-inflammatory activity.