Abstract

SYNTHESIS, CHARACTERIZATION, ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF SUBSTITUTED-N-(2-HYDRAZINYL QUINOLIN 3YL) METHYLENE BENZENAMINE

Swapna Sahu*, Shobhit Srivastava and Sujeet kumar Gupta

ABSTRACT

In this study, an attempt is undertaken to synthesized six new quinoline derivatives (5a-f) and performed Carrageenan-induced rat paw edema was used to test anti-inflammatory activity, and Eddy's Hot plate technique was used to test analgesic activity. Take Dimethyl formamide (DMF) & is cooled to maintain temperature 0-5oC. Then, with mixing, POCl3 (Phosphorous oxy chloride) is added drop by drop. Add acetanilide to this solution and produce 2-Chloro-3-carbaldehyde.[2] After that it react with an ethanolic solution of substituted aniline and dissolved in DMF. For 2 hr, the reaction mixture was refluxed. After that, precipitate was cleaned in ethanol, filtered, dried, and weighed to produce N-((2-Chloroquinolin-3-yl)methylene)2-substituted benzamine (3a-f) which are further allowed to react with hydrazine hydrate. Reaction mixture was refluxed further this mixture was cooled at 24oC and left overnight for separation of compound. Then separated solid recrystallized by ethanol and to produced final derivatives (5a-f). A newly synthesized series of quinoline derivative was confirmed by FT-IR and 1H NMR spectra values. Albino wister rats of either sex, weighing 100-200 gm, were separated into three groups. Group 1 was given 0.2 ml of carrageenan as a control, Group 2 was given Diclofenac (20mg/kg, oral) as a standard drug and Groups 3 were given the test drug and showed distinct results. 3,4-dichloro-N-((2-hydrazinyl quinoline3-yl)methylene) benzamine (5b) was shown with strong analgesic and anti-inflammatory action.

Keywords: Quinoline, Anti-inflammatory activity, Analgesic activity.