Abstract

SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM: A REVIEW, ADVANCEMENTS AND APPLICATION

Nita S. Sonawane*, A. B. Velhal and Dr. Vivekkumar K. Redasani

ABSTRACT

The number of poorly water-soluble drug candidate compounds has been increased in modern approaches. Drug discovery with over 40% of today's compounds being lipophilic with low water solubility. The use of lipid-based drug delivery systems to improve drug solubility, permeability and bioavailability has been widely reported in the literature. There has been a revolutionary interest in nanoemulsions for various pharmaceutical applications since the description of low-energy emulsification processes such as spontaneous and self-nano emulsification. SNEDDS are stable preparations with an increasing interfacial surface diameter differing from ordinary emulsions. SNEDDS generate optically transparent to translucent dispersions with droplet sizes ranging from less than 100 nm. An attempt was made in this review paper to offer an overview of SNEDDS, their mechanism, formulation excipients, SNEDDS potentials, advantages and limitations, advancements and future perspectives of SNEDDS formulations.

Keywords: Nanoemulsion, Oral delivery, Poor bioavailability , Self-nanoemulsification, SNEDDS.