Abstract

FORMULATION AND EVALUATION OF PARACETAMOL SUSPENSION BY USING NATURAL SUSPENDING AGENT EXTRACTED FROM PEDALIUM MUREX SEEDS

M. Sai Vishnu*, A. Lakshmana Rao, T. Divya Sree, T. Mounika, T. Navya Sri and T. Vineela

ABSTRACT

The present work was aimed to formulate and evaluate a new, cheap and effective natural suspending agent that can be used as an effective alternative for traditional suspending agent. The study procedure involved extraction of suspending agent from the Pedalium murex seeds, determination of swelling index, phytochemical testing, Micromeritic properties of mucilage like Bulk density, Tapped density, Carr‟s index, Angle of repose, Calibration of paracetamol, preparation of paracetamol suspensions and evaluated for PH determination, determination of sedimentation volume, redispersibility, determination of flow rate, measurement of viscosity, effect of temperature, drug content, particle size determination and In-vitro dissolution studies. The study showed that the extraction of suspending agent from Pedalium murex seeds. The swelling index was found to be 60% in distilled water, 40% in 0.1N hydrochloric acid and 30% in phosphate buffer pH 7.4. The photochemical test showed contains carbohydrates. As the concentration of suspending agent increases therefore viscosity of suspension increases which ultimately reduces the sedimentation of suspension.

Keywords: Pedalium murex, paracetamol, swelling index, phytochemical testing, Micromeritic properties, sedimentation volume.