Abstract

A PROSPECTIVE STUDY ON ACHIEVEMENT OF NEGATIVE BALANCE IN PATIENTS WITH CHRONIC KIDNEY DISEASE TREATED WITH FUROSEMIDE VERSUS TORSEMIDE WITHOUT UNDERGOING DIALYSIS IN A TERTIARY CARE HOSPITAL

Dr. Greeshma Josephine Raj*, Dr. Delsa P. Andrews, Dr. Binny Babu, Athulya Raj S., Dr. Subash B. Pillai and Dr. Santhosh M. Mathews

ABSTRACT

Loop diuretics are the most potent diuretics. They reduce sodium reabsorption in specific renal tubules, resulting in an increase in urinary sodium and water excretion in the CKD patients to relieve edema and thereby bodyweight. Both furosemide and torsemide of loop diuretic class are used in chronic kidney disease patients as a treatment for edema. In this study the effect of furosemide and torsemide on bodyweight in non-dialysis chronic kidney disease patients were compared. A total of 60 non-dialysis stage 3 or 4 CKD patients were included in this single centred hospital based prospective cohort study. 30 patients in the furosemide group were compared with 30 patients in the torsemide group for effect on bodyweight reduction and achievement of negative balance. The results showed that the bodyweight change between 2 groups did not differ significantly. 3kg of bodyweight reduction was seen after 5 days. Majority of patients in both groups achieved negative balance within first day. 90% of torsemide population achieved negative balance whereas only 73.3% achieved negative balance in furosemide group on 5th day. The study concluded that furosemide is the preferred drug for sudden action and for acute therapy while torsemide is the preferred one for sustained action and for prolonged therapy.

Keywords: furosemide, torsemide, CKD, bodyweight, negative balance, non-dialysis.