Abstract

DESIGN AND DEVELOPMENT OF TRANSDERMAL PATCHES OF TROPISETRON HCL

Nirmal Singroli*, Chanchl Jain and Navjot Singh

ABSTRACT

In this work an attempt was made to formulate and evaluate TDDS for sustained release Tropisetron HCl by solvent casting method. Low molecular weight, good permeability and shorter half-life of Tropisetron HCl made it a suitable drug candidate for the development of transdermal patches. Six formulations were prepared using different polymers in different ratios and combinations, along with plasticizers and penetration enhancer. The films were evaluated for uniformity of thickness, weight variation, drug content, folding endurance, tensile strength, % elongation, % moisture absorption and ex-vivo diffusion studies using kesary chein diffusion cell. The weight variation was found in the range of 65.24 to 67.05. Thickness variation was found to be between 0.025 to 0.048 mm. Tensile strength was found to be between 0.58 to 0.75 for 2 x 2 cm2 patches. The % moisture absorption for all the formulations was in the range of 3.9 to 5.18%.The formulation OND F1 showed the % moisture absorption of 4.5 %.The ex-vivo diffusion study was carried out in phosphate buffer pH 7.4 for 10 hours. Rat skin was used for the diffusion study. The formulation OND 1 showed the best diffusion through the skin. It showed the diffusion of 76.69%.The formulations followed the Higuchi’s model for the drug diffusion study. Since the formulations follow Higuchi’s model, thus they indicate diffusion mechanism. The peppa’s plot showed the n value of 0.721 for formulation OND F1, thus indicating non- fickian diffusion.

Keywords: Transdermal Pateches, Diffusion study, Tropisetron HCl, elongation, Diffusion studies.