Abstract

CHEMISTRY AND PHARMACOLOGICAL EVALUATION OF QUINAZOLINE AND QUINAZOLINE DERIVATIVES – A REVIEW

Merlin Biju John*, Mincy Mathew and Dr. Christy K. Jose

ABSTRACT

Quinazoline is the main six-membered heterocyclic ring system possesses a wide range of promising biological activities. The simple and versatile synthetic methodologies which gives advancement in research and development for years and continued interest in the quinazoline scaffold in medicinal chemistry. The stability of the quinazolinone nucleus has inspired researchers to introduce many bioactive moieties to this nucleus to create novel potent medicinal agents. This article outlined the chemistry and biological activities of quinazoline and its derivatives.

Keywords: Quinazoline, Quinazolinone, Diuretic, Anti- hypertension, Anti-diabetic, Anti-convulsant, Anti-tubercular.