Abstract

EVALUATION OF THE ANTI-INFLAMMATORY EFFECTS OF THE AQUEOUS EXTRACT OF THE BARK OF BARTERIA FISTULOSA

Minoue Kuum Marc Germain*, Tchadji Colince Jules, Atsang A. Kiki Gisèle, Temdie Guemmogne Roméo Joël and DIMO Théophile

ABSTRACT

The present study was carried out to investigate the anti-inflammatory effects of the aqueous extract of the stem bark of Barteria fistulosa. Qualitative and quantitative phytochemical analyses were done. The anti-inflammatory effect of the plant aqueous extract (50, 100, 200 and 400 mg/kg) was investigated on carrageenan and (50 and 100 mg/kg of the aqueous extract) histamine, serotonin or dextran-induced paw edema. Qualitative phytochemical analysis of the Barteria fistulosa revealed the presence of alkaloids, flavonoïds, phenols, saponins, tannins, glycosides, tannins and steroids. The aqueous extract of the bark of Barteria fistulosa at a dose of 50 mg/kg caused a significant reduction in the edema caused by carrageenin during the first 2 hours. The maximum percent inhibition was 50% at the first hour. The effect of this dose (50 mg/kg) was significant as early as half an hour after injection of carrageenin. The 100 mg/kg dose induced significant anti-inflammatory activity during the first four hours. The maximum effect of this dose was 58.33% one hour after injection of carrageenin. The administration of the extract at a dose of 200 mg/kg reduced carrageenin-induced edema by 33.33% after half an hour and 32.71% after 3 hours respectively. It should be noted that the activity of this dose was not significant at any time, as was the action of the extract at the large dose of 400 mg/kg. This high dose of 400 mg/kg induced a maximal inhibition of edema induced by carrageenin by 36.45% (P

Keywords: Barteria fistulosa, Inflammation, Anti-inflammatory, Phytochemical, Ethnopharmacological.