Abstract

TO STUDY THE ROLE AND SIGNIFICANCE OF PRO BNP IN CARDIAC PATIENTS

Dr. J. Raghu Ram*, Ruquia Siddiqa, Ayesha Fatima, Dr. Anupama Koneru, Dr. Rahul Ghogre

ABSTRACT

Aim: The main aim of this study is to know the role and significance of proBNP in cardiac patients. This includes patients with CHF, LV dysfunction, stroke, myocardial infarction etc. Objective 1. The main objective of the study is to know the clinical importance of proBNP in cardiac patients. 2. To analyze the implications of using proBNP for prediction of adverse cardiovascular outcome. 3. To know the BNP levels at different parameters like age,gender , BMI, comorbidities etc. 4. Treatment monitoring. 5. To know the BNP levels before and after the treatment. Methodology: This study includes all the patients of cardiac department who were suffering from CHF, myocardial infarction, LVdysfunction, stroke etc These patients were selected on case reports, lab reports, quality of life and Pharmaceutical care during the study period. The patients are selected based on the study criteria i.e patients undergoing BNP test and are suffering from cardiac diseases. In our study they are complete 150 patients who has undergone BNP test and are diagnosed with cardiac diseases. Results: In our study we have studied the role and significance of BNP in cardiovascular disorders at Aster Prime Hospital, Hyderabad. In our study of 150 patients 67,(45%) patients were female and 83,(53%) were males. In our observed study we found that cardiovascular patients were seen more in femlaes than in males. BNP levels recorded in our patients where from less than 2000pg/ml to greater han 14000pg/ml.BNP levels were observed in patients of greater than 40 years of age. We observed that there BNP levels increases with an increase in age. In our study of 150 patients ,under comorbid conditions 14% were of COPD, DM+HTN were 58%, bronchal asthma 5%, hypothyroidism 3%, obesity 7% and CKD 3% ,When BNP levels were observed against BMI we found that the lesser the weight of the individual greater is the levels BNP. Chief complaints reported by the patients were 35% SOB, Giddiness 14%, chest pain 18%, syncope 7% and nausea and vomiting 29%. Conclusion: We concluded that the biochemical marker, BNP was very helpful in diagnosing cardiac patients. The clinical utility of BNP to rule out cardiovascular outcomes, will remain its major clinical application in routine use and in the treatment of patients .Existing data suggest that the concept “The lower the BNP test result, the better the prognosis of chronic heart conditions of the patients”. The concept “the lower the BNP result the better the prognosis of chronic heart Conditions” is also valid after start of treatment mostly with Diuretics. BNP was found to be most powerful predictor of cardiovascular outcomes beyond heart failure it was also predictive of MI and stroke .The results suggest that BNP measurements will be intrinsic in the future management of heart conditions .it has been established that increased BNP is associated with heart failure severity Continued research will elucidate how to best utilize BNP and its role in the future of health care. Measurement of BNP concentrations may also prove a useful addition to clinical valuation in situations where risk stratification is required for example, in selecting patients with advanced heart failure for transplantation or for guiding referral for device selection in patients at risk of sudden death. Further research will inform this area. BNP have a clear role in the diagnosis of cardiovascular outcomes in patients presenting with complaints like Dyspnea, chest pain etc, monitoring of therapeutic responses, and determining prognosis of acute and decompensated heart conditions.

Keywords: B-type natriuretic peptide, congestive heart failure, diagnosis, monitoring.