Abstract

NIOSOMES: AS PROMISING VEHICLE FOR NOVEL DRUG DELIVERY SYSTEM A REVIEW

H. R. Sachin* and A. R. Shabaraya

ABSTRACT

Novel drug delivery is a recent system which easily promotes and convenient route of administration and while also offering benefits over conventional dosage form. Niosomes are novel drug delivery system (NDDS). They are tiny non-ionic surfactant bilayer vesicles that are formed by hydrating synthetic non-ionic surfactants in aqueous media with or without cholesterol or other lipids, resulting in a lamellar structure that encapsulates both lipophilic and hydrophilic drugs. They are structurally similar to liposomes in that they are made up of bilayers and are thought to be a better carrier for drug delivery due to characteristics such as stability, cost, and storage conditions. Niosomes are a promising vehicle for drug delivery because they are non-ionic, more stable, and less expensive. They are also biodegradable, biocompatible, non-immunogenic, and have structural flexibility. Niosomal drug delivery is potentially applicable to many of pharmacological agents for their action against various diseases. Encapsulation of a drug in the vesicular system is expected to prolong its presence in the systemic circulation and improve penetration into target tissue, as well as potentially lower toxicity if selective uptake is achieved. For the treatment of cancer, viral infections, and other microbial disorders, niosomes have been extensively studied for controlled release and targeted administration. This overview covers the basics of niosomes, including as their structural components, preparation methods, limits, and current applications to a various disorder.

Keywords: Niosomes, Composition, Types, Method of preparation, Factors affecting, Applications.