Abstract

A REVIEW ON PREPARATION AND CHARACTERIZATION OF REVERSE MICELLES BASED LECITHIN ORGANOGELS

Priyanka Rattan*, Rahul Awasthi and Dr. Shivali Singla

ABSTRACT

The solubility and permeation of hydrophilic drugs across skin barrier system are the limiting steps for any topical drug delivery system. Although several approaches have been investigated by the researchers for the development of an efficient drug delivery system but all have their own limitations. Several novel approaches are taken into consideration and reverse micelles based Lecithin organogels are one of them. The reverse micelles have inner hydrophilic core and outer hydrophobic core. The hydrophilic drug can be easily incorporated within inner core. The reverse micelles based Lecithin organogels has shown high efficient in drug permeation through skin. They can be formulated by either of two methods. Method 1 includes the addition of lecithin, isopropyl Myristate and water [RMS-1] whereas Method 2 involves the addition sodium bis (2-ethylhexyl) sulfo-succinate, isooctane, and water [RMS-2]. The reverse micelles formation change the polarity of water allows the solubilization of hydrophilic drug. These reverse micelles are then used for the formation of Lecithin organogels by addition of any gelation agent or by adjusting the water ratio. These systems are evaluated for physical properties, drug content, toxicology, in vitro and in vivo transdermal permeation.

Keywords: Lecithin, Organogels, Reverse micelles, topical route, transdermal, hydrophilic drugs, skin barrier system.