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FORMULATION AND EVALUATION OF EXTENDED RELEASE MATRIX TABLETS OF PROPRANOLOL HYDROCHLORIDE
Bura Jayasree, Lingala Srikanth and Sridhar Babu Gummadi*
ABSTRACT
Hypertension is the most life-threatening disease amongst all lifestyle diseases. So, there is always a need for such a dosage that can release the drug for a long period from a single dose which will reduce the dose burden for the patient. The propranolol HCl is a non-selective beta-adrenergic blocking agent extensively used in various cardiovascular diseases. In the present study matrix tablets of anti-hypertensive drug, propranolol HCl were prepared and evaluated. The HPMC, sodium alginate and xanthan gum was used as a rate retarding polymer. The present study results point out that the rate of propranolol HCL release from xanthan gum matrices is mainly controlled by the drug:xanthan gum ratio. When the concentration of xanthan gum was enhanced, the release of the drug from the matrix tablet was retarded. Keywords: Propranolol HCl, HPMC, sodium alginate and xanthan gum. [Download Article] [Download Certifiate] |