Abstract

ANTIVIRAL ACTION OF THYMOQUINONE (TQ) IN DIABETIC PATIENTS: A SYSTEMATIC REVIEW.

Madhu S. U.*, Harshitha S., Namitha B. Kagal and Honnesh

ABSTRACT

Thymoquinone (TQ) is one of the pure biological component of Nigella sativa (N. Sativa) belongs to the family Ranunculaceae. Thymoquinone has multimodal effects which act as both antiviral and antidiabetic. If a Diabetic patient infected by corona virus, TQ has favorable effect as antiviral especially in Covid-19 by inhibiting virus entry to the host cell by binding to the angiotensin converting enzyme 2 (ACE2) and Heat shock protein 5 (HSPA5) receptor on the spike protein of SARS-CoV-2, due to anti oxidant action of TQ reduces the oxidative stress and also restrain the viral replication i.e. replication/ transcription complex (RTC) by inhibiting the release of viral genetic material (single stranded RNA) in to the cytoplasm and TQ destroys the viral outer envelop by increasing endosomal PH. Simultaneously, decreases the oxidative stress on liver cell, this leads to increasing in the activity of anti oxidant enzyme and decreases the lipid peroxidation. By these two process, TQ enhances the β cells function and increases the insulin production, which results in reducing the risk of Diabetes mellitus (DM) type I. However, TQ may have superior effect as antivial and antidiabetic, hence Diabetic patient may get both beneficial from one molecule i.e. TQ.

Keywords: Thymoquinone (TQ), Nigella sativa (N. Sativa), Covid-19, SARS-CoV-2, Anti Diabetic, Anti viral.