Abstract

A REVIEW ON ANTIMICROBIAL SCREENING NOVEL HETEROCYCLIC TRIAZOLE AND TETRAZOLE DERIVATIVE

Nikhil Mishra*, Parul Srivastav and Amrita Singh

ABSTRACT

A large number of triazoles substituted at position 2, 3 and 4 positions by aryl alkyl or heterocyclic moieties have been reported to possess CNS depressant, antimicrobial.. Also, various tetrazole derivatives have been reported for their antimicrobial and antibacterial activities. Compounds containing 1,2,4- triazoloe moieties fused with quinolone ring are known as powerful antimicrobial, anti-inflammatory, analgesic agent. The literature review showed that among various heterocyclic compounds, Keeping the above points in consideration, a series of hybrid molecule of 1,2,4-triazole and methyl quinolone ring system in a single molecular frame work were synthesized. In case of compounds (3a-3l), compound 3e and 3h showed potent activity against E. coli and MIC value was found to be 8 μg/ml which was comparable with standard antibacterial agent.

Keywords: 1, 2,4-triazole,tetrazole derivative, antimicrobial screening, novel heterocyclic.