Abstract

FLOATING MICROSPHERES A NOVEL APPROACH IN FLOATING DRUG DELIVERY SYSTEM A REVIEW

*Devendra Singh Lodhi, Megha Verma and Pradeep Golani

ABSTRACT

Oral drug delivery systems face a number of challenges, including maintaining drug release and extending the duration of drug presence in the gastrointestinal tract until all the drug has been consumed. Fully released after a predetermined period of time Gastric emptying is a process that occurs when the stomach is empty. Intricate, highly in consistent process that creates an inconsistency. It is not known how well drug delivery systems will perform in vivo. To do so, click here. Efforts have been made to develop a controlled environment to reduce this variability the body for a long time. Actives with an upset stomach may find it extremely useful. The upper small intestine has a window for absorption of nutrients. Floating microspheres that enhance drug retention and provide sustained action in the stomach for drugs that are poorly soluble or unstable in intestinal fluids, they can be very beneficial. As a result of their lower bulk density than gastric fluids, floating drug delivery systems (FDDS) float in the stomach for a long period of time. A longer drug retention time and a slower metabolism are needed as a result to ensure long-term efficacy because floating microspheres in the stomach may increase a medication's retention time, the drug's effects will last longer. To get a relatively better response, FDDS dosage forms are beneficial in cases of diarrhoea and vigorous intestinal movement. In such cases, floating drug delivery systems (FDDSs) are useful. These are expected to float for a long period of time on the stomach's contents. It is possible to take gastro retentive dosage forms in many different forms, such as tablets or capsules. As a result of their wide range of applications in drug delivery, hollow microspheres are attracting a great deal of attention. This prevents the drug from being released prematurely because it is distributed evenly throughout the gastric fluid. Reviewing recent literature is the purpose of this review.

Keywords: Floating microspheres, Floating drug delivery systems, Microsphere, GRDF, Long term Efficacy.