Abstract

PYRAZOLE-PROMISING ENTITY FOR BIOLOGICAL ACTIVITY: AN REVIEW

Maneshwar T.*, Hemalatha S., Nagaraj P., M. Rammohan, Mounika N., Shanthi Priya D. K. and Vasudha Bakshi

ABSTRACT

Various bioactive heterocyclic compounds containing the pyrazole nucleus showed clinical and biological applications. Pyrazole scaffold has been found in many of the important synthetic drug molecules which gave a valuable idea for treatment and binds with high affinity to the multiple receptors helpful in developing new useful derivatives. Pyrazole derivatives possess various biological activities, i.e., anti-inflammatory, analgesic, antidiabetic, antioxidant, antimicrobial, ant tubercular, anticancer, antimalarial, antiviral, anticholinesterase activities, etc. Those created interest among researchers to Design, synthesize a variety of pyrazole and its derivatives. From the literature review, it is revealed that pyrazole and its derivatives have diverse biological activities and also have an immeasurable potential to be explored for newer therapeutic possibilities.

Keywords: Pyrazole, Antidiabetic, Analgesic, Anti-inflammatory, Antioxidant, Antimicrobial, Anticancer, Antiviral, Antitubercular, Anticholinesterase activities.