Abstract

TO STUDY THE EFFICACY & SAFETY OF ALLOPURINOL ALONE & IN COMBINATION WITH FEBUXOSTAT IN HYPERURICEMIC PATIENTS.

Dr. Tafazzul Hussain, Dr. Musarrat Sultana, Dr. Shamaila Khalid, *Prof. Dr. Syed Saud Hasan, Prof. Dr. Fuad Shaikh and Dr. Nabeel Hasan

ABSTRACT

Introduction: Uric acid is an important constituent, enlist in numbers of physiological & pathological activities in the human body which may undergo to different diseases. Hyperuricemia is recognized, when uric acid raised more than 6.8 mg/dL. Xanthine oxidase inhibitors are the key drugs in reducing the sUA. Objective: Interventional clinical study, conducted at Medical OPD, Civil Hospital Karachi, during the period October 2018 to April 2019. To assess the improvement, safety and tolerability of Allopurinol 300mg/daily & combination of Allopurinol plus Febuxostat 80mg/daily in asymptomatic hyperuricemic patients. Material & Methods: The designed study was approved by BASR & ERB of Hamdard University Karachi. Initially 70 enrolled patients, 60-patients of sUA>6.8 mg/dl were registered, after fulfilled the inclusion and exclusion criteria and written consent, detail history and biochemical assessments measured at day 0, repeated at day 30, 60 and 90, keep in case record file, for final analysis. Patients divided Group A, (Allopurinol) & B (Allopurinol plus Febuxostat) treated & sUA, biochemical assessments, to estimate the improvement, safety and tolerability of the drugs. Results: Group-A baseline uric acid mean 8.79 ± 0.98 change to 6.40 ± 0.86 with percentage change was 27%, while in Group-B treated patients sUA mean 9.22±0.83 to 5.96 ± 0.68 with percentage change was 39%. Mean difference ± SD of serum uric acid in Group-A is 2.39±1.15 with Group-B mean is 3.62 ± 0.87. Drug safety was determined by adverse effects and blood examination, follow up at day-90 from baseline. Conclusion: Improvement reported by mean reduction of uric acid & no reported serious adverse effects, results were highly significant.

Keywords: Allopurinol, Febuxostat, Uric acid, Serum creatinine, Blood chemistry.