Abstract

SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF SCHIFF'S BASE

*Dhiraj Tade, S. G. Jawarkar, M.D. Game, Nikita G. Khandelwal

ABSTRACT

Schiff bases are aldehyde or ketone like compounds in which the carbonyl group is replaced by an imine or azomethine group. They are versatile ligands which are synthesized from the condensation of primary amines with carbonyl groups. Such compounds were characterized by different physico-chemical techniques like, melting point, elemental analysis, IR spectroscopy, UV-visible spectroscopy, NMR, Molar conductance and metal analysis. These compounds are very important in medical and pharmaceutical fields because of their Wide spectrum of biological activities. The free ligands and their metal complexes have been screened for their antimicrobial activities against the bacterial strains such as Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa., fungi (Aspergillus fumigates and Candida albicans) and yeast. Most of them show biological activities such as antibacterial, antifungal as well as antitumor activity. Transition metal complexes derived from the Schiff base ligands with biological activity have been widely studied. In continuous search for better activity drugs ahead of the existing antimicrobial agents which have been severally reported to show a declining action against todays’ pathogens due to many human and behavioural factors; this work was designed to obtain or otherwise an improved antimicrobial agents through modification of the existing drugs using some Schiff bases containing drug with amines. These ligands were complexed with some transition metals and the newly synthesized compounds characterized and their antimicrobial potency evaluated. At the end of the analysis, the work afforded stable derivatives from Schiff bases.

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