Abstract

IN VITRO ANTIBACTERIAL, ANTIFUNGAL, CYTOTOXIC AND ANTICANCER STUDIES OF Co(II), Ni(II) AND Cu(II) METAL COMPLEXES OF A NEW MANNICH BASE LIGAND N- [MORPHOLINO(PHENZYL)METHYL]BENZAMIDE L.MURUGANANDAM

Dr. Loganathan Muruganandam

ABSTRACT

The coordination complexes of Co(II), Ni(II) and Cu(II) derived from N-[Morpholino(phenzyl)methyl]benzamide(MBB) have been synthesized by Mannich condensation reaction. These compounds have been characterized by elemental analysis, IR, molar conductance, electronic spectra, 1H & 13C-NMR, FAB-mass, ESR, magnetic susceptibility and thermal analysis. Analytical data reveal that all the complexes exhibited 1:1 (metal: ligand) ratio with coordination number 4 or 6. IR data shows that the ligand coordinates with the metal ions in a bidentate and tridentate manner through the carbonyl oxygen, azomethine nitrogen and amido nitrogen. The Mannich base and metal complexes are active against the six bacterial species and two fungal species. Cytotoxic and anticancer activities of all the compounds were also studied. These studies indicate that the activity was increased in the complexes relative to the parental ligand.

Keywords: Molecular architecture, Stereochemistry, Axial symmetry, Chelation theory.