Abstract

FORMULATION AND EVALUATION OF ZANAMAVIR CONTROLLED RELEASE FLOATING TABLETS BY USING HYDROPHOBIC POLYMERS

Dr. Sathya Surya Prasad Ch.* and B. Jhansi

ABSTRACT

The purpose of this research was to develop Zanamivir controlled release floating tablets. Zanamivir is an antiviral drug. However, it is not a cure for these infections. Zanamivir decreases the severity and length of these outbreaks. It helps the sores heal faster, keeps new sores from forming, and decreases pain and itching. This medication may also help reduce how long pain remains after the sores heal. In addition, in people with a weakened immune system, Zanamivir can decrease the risk of the virus spreading to other parts of the body and causing serious infections. Formulations of Zanamivir 600 mg were formulated by direct compression technique using different hydrophobic polymer grades such as HPMCK15M & Carbopol 934 were used as polymers in different concentrations and other ingredients are Micro crystalline cellulose (MCC), sodium bi carbonate, citric acid and Magnesium stearate before the formulation the granules are evaluated by pre-compression studies. The obtained tablets were evaluated with different post-compression parameters like hardness, friability, thickness, weight variation, drug content, floating lag time, In-vitro dissolution studies. The formulation F1 was selected as an optimized formulation because it gives best results in terms of in - vitro drug release in a controlled release manner and best fitted to zero order model with r value of 0.824.

Keywords: Zanamivir, HPMC K15M, Carbopol 934, Micro Crystalline Cellulose (MCC), Sodium bi carbonate, direct compression method, Control release Tablets.