Abstract

DETERMINATION OF SAFETY AND EFFICACY OF HARPAGOSIDE WITH DICLOFENAC IN POST OPERATIVE PAIN MANAGEMENT: A PROSPECTIVE COMPARATIVE STUDY

Bhushanam Gayatri*, Kursam Sahaja, G. Sadasiva Rao, Dr. S. Uma Shankar, Thokala Lakshmi Mounika and Kotha Pavani

ABSTRACT

Background information: Due to the low rate of complete recovery from postoperative pain after surgeries shows significant impact on the health and quality of life of patients and their families by causing pain, loss of function and mobility, depression, distress and anxiety, financial burden and prolonged hospital stays. Evidence suggests that postoperative pain impose significant and underappreciated burden to the individual, the healthcare system and the society as a whole. Harpagoside dose is 5mg which is available in capsule form. In this study, oral dosage form of harpagoside was used to determine its effect in the postoperative pain management of acute and chronic pains after surgeries. Materials and methods: It is an comparative study which involves 50 patients suffering from postoperative pain and were divided into 2 cohorts (test harpagoside and control-diclofenac). Visual analogue scale was used for the comparison of pain management in test and control groups in postoperative pain management. Results: Out of 50 subjects taken 25 subjects are treated with harpagoside and 25 subjects are treated with diclofenac. Of the 50 subjects taken 25 subjects are males and 25 subjects are females. Of 25 Subjects treated with harpagoside 10 subjects were discharged on day 3 which is early, 14 subjects are discharged on day4 and 1 subjects was discharged on day 5 without any complains of pain. Of 25 subjects treated with diclofenac 1 subject was discharged day 4, 12 subjects were discharged on day 5, 3 subjects are discharged on day 6 and 5 subjects are discharged on day 7 which is delayed and still with complaint of pain. statistical analysis was done in SPSS 16.0 software by an appropriate statistical methods independent T test for knowing the significant p-value

Keywords: Postoperative pain management, Diclofenac, Harpagoside, Visual analogue scale.