Abstract

REVIEW ON GOUT DISEASE AND THEIR TREATMENT

Sandhya Gorakh Bansode*, Prof. K. N. Tarkase, Sagar Babasaheb Khedkar, Disha Vikas Kamble, Akshay Nagnath Bhalekar

ABSTRACT

Gout is a paiful condition that occurs when uric acid produced by the body is stored as crystals in the joints and soft tissues. It is a disturbance of uric acid in the body. Gout is a disorder of purine metabolism, and occurs when it final metabolite, uric acid, crystallizes in the form of monosodium urate, precipitating and forming deposits (tophi) in joints, on tendons, and in the surrounding tissues. It is a important to recognize that it is a systematic disorder caused by either overproduction or underexcretion of uric acid. High serum uric acid, or hyperuricemia, is the causative agent in gout; however, hyperuricemia is not pathomnemonic of gout. Affecting factors – such as alcohol abuse, obesity, and genetics determine a predisposition to developing a gout. There are different types of gout such as Asymptomatic gout, Acute gout, Interval gout, Chronic gout and Pseudogout. Alcohol consumption, age, postmenoupausal, diet, dehydration, kidney and thyroid disorders, diuretics and cyclosporines intake, etc are the reasons of causes gout. People with gout can develop more severe conditions, such as: Recurrent gout, Advanced gout and kidney stone. Joint fluid test, blood test, x-ray imaging, ultrasound, dual- energy computerized tomography (DECT) these test are help to identifying the characterization of gout. Other important points in its management includes patient education, diet and life style changes, as well as the drug used in the treatment of gout attack.

Keywords: Gout, Hyperuricemia, Uric acid, Monosodium urate crystals, Purine metabiltes, Pathophysiology of gout, Allopurinol.