Abstract

A REVIEW ON NOVEL DRUG DELIVERY SYSTEM: GASTRO RETENTIVE DRUG DELIVERY SYSTEM

Sheetal Saini*, Anshul Sharma, Subhneesh Kumar, Suryakant Verma and Sachin Tyagi

ABSTRACT

Oral delivery of drugs is by far the most preferable route of drug delivery. This route has high patient acceptability, primarily due to ease of administration. Effective oral drug delivery depend upon the factors such as gastric emptying process, gastrointestinal transit time of the dosage form ,drug release from the dosage form, and site of absorption of drug. In the recent years, scientific and technologicaladvancement have been made in the research and development of gastroretentive drug delivery system. Henceforth a widespectrum of dosage form have been developed for the drugs which have narrow absorption window, unstable atintestinal pH, soluble in acidic pH and have site of action specific to stomach. The purpose of writing this review was to focus on approaches which are currently utilized in the prolongation of gastric residence time. These include floating system, swelling, bio/mucoadhesive system, high density system. The present review addresses briefly about the formulation consideration for GRDDS, factors controlling gastric retention, merits, demerits, approaches and evaluation of gastroretentive drug delivery systems.

Keywords: Gastroretentive drug delivery system (GRDDS), Floating System, swelling, bio/ mucoadhesive System, high density system, low density system, stomach, etc.