Abstract

FORMULATION AND EVALUATION OF COW GHEE AS A BASE FAST AND SUSTAINED RELEASE CHLOROQUINE PHOSPHATE SUPPOSITIORIES

Chalakanti Suryakumari*, A.Anusha, P.Anitha, D.Ravindra

ABSTRACT

Chloroquine phosphate treatment of severe malaria must be rapidly effective. The Suppositories may be valuable for childhood malaria when circumstances prevent oral or parenteral therapy. The aim of this study was to prepare fast and sustained release hollow type of Chloroquine phosphate suppositories. in first part of this study the natural bases cow Ghee were compared with synthetic bases. The inner layer were developed by using hydrophobic base with hydrophilic polymers. The investigations of developed formulations contains both fast and sustained release of Chloroquine phosphate from the same device was obtained using hollow type suppositories for effective treatment of malaria in children's.

Keywords: Chloroquine phosphate, fast and sustained release suppositories, Fusion or melt moulding method, Cow ghee, synthetic bases.