Abstract

FORMULATION DEVELOPMENT AND INVITRO EVALUATION OF DULOXETINE TRANSDERMAL DELIVERY SYSTEM

Kabita Banik*, Menda Teja Sri, Moguram Vyshnavi, Mangalagiri Sharath Chander, Maram Yashwanth Reddy

ABSTRACT

Different polymeric Patches containing Duloxetine were prepared and evaluated for physicochemical, in vitro drug release and Kinetic studies.[1] The IR spectral analysis of Duloxetine showed that the principal peaks and for the mixture of Duloxetine with different polymers additional to the principal peaks, some additional peaks were observed with physical mixtures, which could be due to the presence of polymers. The presence of all the characteristic bands due to functional groups in polymer mixtures suggests that there is no interaction between the drug and polymers used in the present study.[2] Transdermal patches with Ethyl cellulose and HPMC E15 showed better release than patches with ERS 100 and HPMC E15. The release rate was increased with an increase in HPMC E15 content. The release kinetics of the optimized formulations followed zero order and release mechanism was Non-fickian diffusion rate controlled mechanism. The research work gives a rational guideline for formulating a controlled release transdermal delivery system DT9 for effective therapy.[3]

Keywords: Transdermal drug delivery, Duloxetine, HPMC E15, Ethyl cellulose, Solvent evaporation method, Kinetic drug delivery system, FTIR.