Abstract

DEVELOPMENT AND EVALUATION OF NON STEROIDAL ANTI INFLAMMATORY FLURBIPROFEN LOADED ALBUMIN MICROSPHERES

*J. Narasimha Murthy, K. Narasimhulu, A. Nagendra, K. Gafoor, C. G. Vamsi and
G. Venkatesh

ABSTRACT

Non steroidal Anti inflammatory product namely Micro spheres for Flurbiprofen loaded Albumin to overcome the drug-related adverse effects like Headache, nervousness or anxiety, depression,memory problems, improve its bioavailability in different gastrointestinal pH conditions. Total nine formulation batches (F1-F9) were formulated using sodium alginate alone and combination with SodiumCMC, and pectin polymer as drug release modifiers in various proportions and investigate for physicochemical properties and drug release potential. All investigated properties showed satisfactory results. While increase in the concentration of sodium alginate and other polymer dispersions increased sphericity, size distribution, flow properties and mean diameter of the Micro spheres. The drug entrapment efficiency obtained in the range 70.4% to 95.2%. Increase in the concentration of calcium chloride was significantly affects the mean diameter but no appreciable change in morphology and drug release behaviour. In-vitro study proves that drug release slowly increases as the pH of the medium is increased. The drug release in batch F1, F2 and F3 showed more faster release than F7, F8, F9 but optimum sustained release was observed in the batch F4, F5, F6 containing sodium alginate coated with Pectin. The mechanism drug release from Micro spheres was found to be following Case-II transport. From the study it was concluded that controlled release loaded Albumin Flurbiprofen Micro spheres can be developed successfully by using ionotropic gelation technique.

Keywords: Microencapsulation; Ionotropic gelation; Micro spheres; Sodium alginate; Sodium CMC; Pectin; pH dependent,