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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

SYNTHESIS CHARACTERIZATION AND QUANTIFICATION OF PROCESS RELATED QUINOLONE IMPURITY IN OFLOXACIN BULK

Gharmalkar Samruddhi K.* and Prof. A. L. Ware

ABSTRACT

The present research work deals with synthesis, characterization and quantitation of process related impurities of Ofloxacin. The Impurities was synthesis by Skraup Synthesis method. The synthesis impurity was characterized by analysis such as UV. In UV method 0.1N HCL was used a solvent and from 2-10ug/ml conc. were done. For quantitation analysis RP-HPLC method was developed. In this method mobile phase was taken as (Acetonitrile: Methanol) ration was taken (80: 20 v/v). The RP-HPLC method was found to be linear, precise, rugged, robust & accurate. The amount of impurity present in bulk was found within limit.

Keywords: Impurity, Ofloxacin, UV Spectroscopy, RP-HPLC.

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