Abstract

SYNTHESIS OF SUBSTITUTED 6, 7-DIMETHOXY-4-(3, 4, 5-TRIMETHOXYPHENYL)-3, 4-DIHYDRONAPHTHALEN-1(2H)-ONE AND THEIR APOPTOSIS STUDY

Ranjini P., Chaitramallu M. Shilpa, Devaraju Kesagodu* and Prof. Y.B. Basavaraju

ABSTRACT

The field of biomedical analogs of podophyllotoxin is more in its infancy, but the explosion of interest in these molecules as inherently active therapeutic agents is increasing. There is growing interest in the design and synthesis of novel biocompatible analogs. The series of novel substituted podophyllotoxin derivatives were synthesized under mild conditions with satisfactory yield. Auto dock server analysis of the these analogs structure showed that the compounds were shown to interact with the proteins involved in Bcl-xL mediated pathway with inhibition constant of 0.000149 and 0.000584 for 5G and 5C respectively The recorded results of lipid peroxidation with treated samples were increasing with increasing concentration.

Keywords: Podophyllotoxin, tetralone docking study, ETA cell Tryphan blue assay, Auto dock.