Abstract

POLYMERIC NANOSPONGES AS A CARRIER FOR GLEBENCLAMIDE IN MANAGEMENT OF DIABETES

Ramakrishna A. Shabaraya*, Shripathy Dharmasthala, Ankit S. Parulkar, Krishnananda Kamath and Viresh Chandur

ABSTRACT

The aim of the present study is to improve the bioavailability of the poorly water soluble drug glebenclamide, by preparing nanosponges using emulsion solvent evaporation method with high pressure homogenizer. Preformulation studies concluded that there were no chemical interactions between drug and polymer. Nanosponges containing glebenclamide were successfully formulated using emulsion solvent evaporation method and evaluated. Formulations were prepared by emulsion solvent diffusion method using ethyl cellulose as polymer and polyvinyl alcohol as surfactant (2 %to 4%). The formulations were prepared by using high speed homogenization with the optimum speed of 15000 RPM, yielded reduced particle sizes from 700 nm to 400 nm. The percentage yield was found to be between 70 to 72 % with some exception to GECN 7 which showed 80% yield. The particle zeta potential studies showed the particles size in the range of 400 nm to 600 nm with PDI of 0.300 to 0.600 indicated good drug loading but resulted in monodisperse. Nanosponges were successfully prepared and showed better release than pure drug.

Keywords: Nanosponges, Glebenclamide, Solvent evaporation, Homogeniser, Zeta potential.