Abstract

IN-VIVO ANTITUBERCULAR AND IN-VITRO ANTIMALARIAL POTENTIAL OF EUPHORBIA HETEROPHYLLA LEAVES EXTRACTS

Pallavi Dattatray Namdas* and Krishna Shreeramji Pathade

ABSTRACT

This study was carried out to perform antitubercular and antimalarial activity of Euphorbia heterophylla leaves methanolic extract (EHLME). Euphorbia heterophylla is a branched shrub which belongs to family Euphorbiacea. Plant have shown various activity such as antineoplastic, allelopathic, skin-irritant, wound healing etc. but have not reported antitubercular and antimalarial which are considerably major activities. So The extraction was performed by using scientific microwave oven successively and methanolic extracts were used to perform the activities. Microplate almar blue assay was the method used to perform antitubercular activity against mycobacterium tuberculosis (Mtb). Concentrations 100 μg/ml, 50 μg/ml, 25 μg/ml were sensitive against Mtb which inhibited the growth of bacteria by showing blue colour in the well. Regarding the antimalarial activity 100 μg/ml conc. was showing significant activity.

Keywords: Microwave, Methanolic, Antitubercular, Antimalarial, Euphorbiaceae.