Abstract

BUCCAL AND SUBLINGUAL DRUG DELIVERY OF PEPTIDES

Nikhil Thorane*, Dr. Kanchan P. Upadhye and Harshita Suke

ABSTRACT

The field of oromucosal drug delivery system has crossed significant milestones from the systemic delivery of medicines. Peptides are currently emerging as a major class of therapeutic drugs. a wide variety of polypeptidic drugs have been evaluated for buccal absorption. Some of these include gastrointestinal peptides (secretin, substance P), pancreatic hormones (insulin, glucagon), anterior pituitary polypeptides (adrenocorticotropins, growth hormone), posterior pituitary oligopeptides (oxytocin, vasopressin and their analogues), hypothalamic-releasing-hormones (protirelin, gonadorelin, growth hormone-releasing factor hormone, somatostatin) and their derivatives (e.g. the gonadorelin agonists, buserelin, histrelin and nafarelin), as well as enkephalins, calcitonin and interferons. This paper suggest the use of oromucosal delivery system for the peptides and polypeptides molecules. In this paper we have also includes the different studies that are completed on peptide molecules by buccal and sublingual route which shows better results. This study will help the researches to develop oromucosal peptide delivery system.

Keywords: Buccal, Sublingual, Mucoadhesion, peptides, calcitonine, Insulin, Vasopressin, Protirelin.