Abstract

CONTRIBUTION OF JAK-STAT SIGNALING PATHWAYS AND NOVEL APPROACHES IN SITE SPECIFIC DRUG DELIVERY FOR MALIGNANT TUMOURS: A SYSTEMATIC OVERVIEW

Snehal Gajanan Shinde*

ABSTRACT

Cancer is prevalent cause of mortality around the world. As we know JAK STAT signaling pathway regulates cellular processes like cell division, cell death and immune regulation. They also control cell survival, proliferation, differentiation and hematopoiesis. Aberrated activation of JAK and STAT signaling pathway promote tumour growth or tumorigenesis. Dysregulation of this signaling pathway also cause numerous immune inflammatory diseases. As the JAK and STAT3 play an important role in the signaling pathway is the target strategy for intracellular drug development. The therapeutic approaches like JAK and STAT inhibitor, natural agents including phytochemicals which exhibit potent anti-cancer activity via various mechanisms are mentioned in this topic. Based on comprehensive analysis of literature several chemical as well as phytochemical exerts therapeutic and cancer preventive effect through regulation of JAK and STAT signaling pathway. Future perspective related to preclinical and clinical research is necessary to completely comprehend the capability of modulating JAK and STAT signaling to achieve efficient cancer control and treatment. This topic includes structural morphology of JAK and STAT domain, regulation signaling pathway of JAK and STAT, pathological or aberrant signaling of JAK and STAT, effect of mutagen or mutative agent in the JAK STAT signaling pathway, current approaches in the treatment of malignancy related to JAK STAT and future strategies which control and prevent malignancy associated with JAK - STAT signaling pathway.

Keywords: Malignancy, JAK-STAT, Signaling pathway, JAK mutation, STAT3 inhibitor, SBDD and computational drug design.