Abstract

RECENT ADVANCES IN THE BIOLOGICAL ACTIVITIES OF INDOLE DERIVATIVES; A REVIEW

Surendra Kumar Gautam*, Umesh Kumar and Arti Devi

ABSTRACT

Indole is one of the most significant heterocyclic rings, and it has been used as a privileged scaffold in drug development and biological activity determination. The indole scaffold has been identified as a critical component of the new compounds. The indole core moiety is present in indole synthesis. Indole scaffold is one of the most promising heterocyclics found in natural and synthetic sources, with anti-inflammatory, anti-HIV, antitubercular, antimalarial, anticonvulsant, antidiabetic, antihypertensive, analgesics, antidepressant, anticancer, antioxidant, antifungal, and antimicrobial activity, among other biological activities. Because of their numerous biological uses, indole derivatives are of great interest. We've attempted to summarise the key pharmacological properties of indole derivatives here. In the review, it is revealed that indole derivatives have a wide range of biological functions, as well as a tremendous potential for new therapeutic applications.

Keywords: Indole, Anti-inflammatory, Anti-HIV, Anti-malarial, Analgesic, Antioxidant.