Abstract

HYPOGLYCAEMIC ACTIVITY OF PSIDIUM GUAJAVA LINN. FLOWERS AGAINST ALLOXAN INDUCED DIABETES IN MALE ALBINO RATS

Priyadharshini.G and Anuradha R*.

ABSTRACT

Over the past decade, herbal medicine have been accepted universally and they have an impact on both world health and international trade. Diabetes mellitus is a metabolic disorder in the endocrine system. Plants provide a potential source of hypoglycemic drugs and are widely used in several traditional systems of medicine to prevent diabetes.Qualitative phytochemical analysis of aqueous extract of flower of psidium guajava was carried out with a view of developing leads for a new therapeutic products. The study was designed to investigate the hypoglycaemic effects of oral administration of aqueous extracts of psidium guajava flower in alloxan induced diabetic rats. After oral administration of the flower extract to diabetic rats, the blood glucose level significantly reduced, which is much faster and more than that of metformin. The aqueous extracts of flower of psidium guajava significantly reduced plasma glucose, creatinine, urea, AST, ALT, ACP, ALP, LPO, glucose-6- phosphatase and fructose1,6 bisphosphatase but increased level of serum insulin, protein, CAT, SOD, glycogen synthase and hexokinase. For all the above biochemical parameters observed and it was reverted toits normal level after flower extract treatment. The present investigation suggests that flowers of psidium guajava exhibit hypoglycaemic activity in alloxan induced diabetes in experimental rats.

Keywords: Diabetes mellitus, alloxan, Psidium guajava, hypoglycaemic activity, metformin, blood glucose.