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EFFECT OF PIOGLITAZONE ALONE AND IN COMBINATION WITH SULFASALAZINE ON ACETIC ACID- INDUCED COLITIS IN RATS
Marwa K. Mohsen, Mona O. Abdelhalim, Lubna O. Abdel-Salam, *Dina A. Aly Labib
ABSTRACT
Back ground: Ulcerative Colitis (UC) is an idiopathic disease of colonic mucosa. Drugs being used just alleviate the symptoms but do not cure the disease and have some limitations owing to their severe side effects. Consequently, looking for new agents that are more effective and cause fewer side effects are needed. Aim of this work: The aim was to study the possible anti- inflammatory effect of Pioglitazone on acetic acid- induced UC in albino rats. Methods: Rats were randomized in 5 groups; Group I " Non-ulcerated, Non-treated group", Group II: “colitis, AA- ulcerated, Non-treated” group", Group III" colitis, sulfasalazine-treated group", Group IVa "colitis, Keywords: Ulcerative Colitis, Sulfasalazine, Pioglitazone, Acetic Acid- induced colitis in rats. [Download Article] [Download Certifiate] |