Abstract

CHEMICALLY INDUCED ALZHEIMER’S DISEASE IN EXPERIMENTAL ANIMAL MODEL

Shraddha Desai* M. Pharm, Shahranagoud Biradar M. Pharm and Sandeep Chandakavate M. Pharm,

ABSTRACT

Alzheimer’s disease (AD) is an irreversible, progressive brain disease that slowly destroys memory, thinking skills and eventually the ability of performing simple tasks such as wearing cloth and combing hair, operating phones etc. This all mainly because of degeneration of neurons in the brain and deposition of neurofibrillary tangles (tau) and senile plaques (beta amyloid) in the brain cells and it is the most common form of dementia that usually starts in late middle age or in old age (In between or above 60 years). AD which has occurred by chemical agents in animal models can be very helpful in understanding the mechanisms of the disease with its treatment. Nowadays, many researchers have reported various models of AD but there are some models which demonstrated that the AD can be induced only by using certain chemicals such as colchicine, scopolamine, okadaic acid, streptozotocin, and trimethyltin etc. Without any complication and this is an attempt towards chemically induced AD in animal models.

Keywords: Alzheimer’s disease; Animal models; Memory impairment.