Abstract

FORMULATION AND IN VITRO EVALUATION OF CHRONOMODULATED DRUG DELIVERY OF LEFLUNOMIDE

Mayuri Bodige*, B. Agaiah Goud and M. Bhagavan Raju

ABSTRACT

At present scenario the drug regimen based on circadian rhythm is recently gaining much attention worldwide by researchers. Justification behind it is that, there are various diseases like asthma, hypertension, and arthritis show circadian variation that demand time scheduled drug release for effective drug action. A chrono delivery system, based on biological rhythms, is a state-of the- art technology for drug delivery. The aim of present work is formulate and evaluate a press coated pulsatile release tablets of Leflunomide using pH sensitive polymers (eudragit L-100) in order to achieve a predetermined lag time for chronopharmacotherapy of arthritis. Leflunomide, is an immunosuppressive disease-modifying antirheumatic drug (DMARD), used in active moderate-to-severe rheumatoid arthritis and psoriatic arthritis. It is a pyrimidine synthesis inhibitor that works by inhibiting dihydroorotate dehydrogenase. The tablets prepared were evaluated for different properties like bulk density, tapped density, Angle of repose and Carr’s index), hardness, thickness, weight variation, friability, drug content uniformity and in vitro drug release study.

Keywords: Leflunomide, Chronomodulated, Supradisintegrants.