![]() |
|||||||||||||
|
All | Since 2019 | |
Citation | 5450 | 3969 |
h-index | 23 | 20 |
i10-index | 134 | 84 |
EXPLORATION OF MULTIFACTORIAL ROBUSTNESS STUDY BY BOX-BEHNKEN DESIGN USING BOCEPREVIR AS INVESTIGATIONAL CANDIDATE
Majumder Manish*, Pasha T. Yunus and Bevinhalli Ramesh
ABSTRACT The Box-Behnken Design is efficient design for fitting second order polynomials to response surface. So The Multifactorial robustness study is investigated by using Box-Behnken design. The working points for robustness study have been selected and subsequently investigated on the basis of two criteria: first criteria was to maximise resolution and another is to minimise asymmetric factor. The three investigated parameters are determined to be % Organic Modifier- 89%±1, Flow rate- 0.9±1 and pH- 5.4±1 for the conformation of robustness of the method. To evaluate the robustness the 17 experience are carried out using Box-Behnken design. The statistical analysis of the experimental results confirm the robust point of the method. Keywords: Robustness, Box-Behnken, Boceprevir, Derringer’s desirability function. [Download Article] [Download Certifiate] |