Abstract

A REVIEW ON GRANULATION TECHNIQUES

Prashant Jadhav*, Nagesh Aloorkar and Suresh Sudke

ABSTRACT

Granulation is a dimensions expansion process in which fine or coarse particles are turned into physically stronger and bigger agglomerates with high flow properties, improved compression characteristics, and homogeneity, preventing blend component segregation, improving content uniformity, and removing excessive fine particles. Granules range in size from 0.2 to 4.0 mm, liable on their intended application. The proportions of the granules is determined by the amount of granulating liquid used and the pace at which it is fed. The selection of a granule preparation technique necessitates a detailed understanding of the drug's physicochemical qualities, excipients, and needed flow and release qualities, to mention a few. Spray drying, roller compaction, high shear mixing, and fluid bed granulation are some of the technologies that are now accessible. The goal of this study is to look at some of the most prevalent and unique granulation methods, such as pneumatic dry granulation, steam granulation, moistureactivated dry granulation, thermal adhesion granulation, and freeze granulation and foamed binder or foam granulation.

Keywords: Types of granulation methods, Wet granulation, Dry granulation, Advance granulation methods.